Clinical trial has high added value
It is a plan that recorded specific details
· How clinical trials should be performed
Including all aspects of the research study
· participant inclusion / exclusion criteria
· test schedules and procedures
· medications and their dosages
· methods used to analyze the data collected
- By protocols, experiment could get validity
2. F.M.D (Foot-and-mouth disease)
1) Definition
Foot-and-mouth disease is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovid.
2) Clinical signs
The disease is characterized by high fever that declines rapidly after two or three days; blisters inside the mouth that lead to excessive secretion of stringy or foamy saliva and
Clinical trial has high added value
It is a plan that recorded specific details
· How clinical trials should be performed
Including all aspects of the research study
· participant inclusion / exclusion criteria
· test schedules and procedures
· medications and their dosages
· methods used to analyze the data collected
- By protocols, experiment could get validity
Management
Three factors that usually are considered
1) Fetal age and thus maturity
2) Labor
3) Bleeding and its severity
? Preterm + no persistent active bleeding
→ Close observation
? Near term + not bleeding
→ Scheduled cesarean delivery
※ Timing is important to maximize fetal growth but to minimize the possibility of antepartum hemorrhage.
※ Data are sparse rega
ㅁ Clinical Manifestations
- common seizure disorder during childhood, 소아에서 가장 흔한 경련성 질환, 모든 소아의 3-4%에서 경험
- 3개월에서 5세 사이에 많이 발생(5세 이후에는 뇌의 발달로 드묾)
- Generally an excellent prognosis
- Differential diagnosis
- sepsis or bacterial meningitis
- A convulsion associated with an elevated temperature gre
1. Identifying Information
A. Name: Conchita Morales
B. Age: 35
C. Sex: Female
D. Job: Research chemist
2. Conceptualization
Axis IV based on DSM-V-TR
Axis I: 300.21 Panic Disorder With Agoraphobia
Axis II: none
Axis III: Past experience of anti-anxiety medication
Axis IV: job promotion offer from boss recently
Axis V: GAF (61~
3 methods in Phase 1
Standard Method
Rule-based design
proceeds with
cohorts of three
patients.
If one of the first
three patients
experiences toxicity, three more patients will be treated.
Continual Reassessment Method(CRM)
All patients are
treated maximum tolerated dose.
(MTD)
The original CRM allowed for multiple dose escalations and de-escalations.
Accelerated
Titra
Clinical Trials
Ⅰ. About Clinical Trial.
1. Definition of clinical trials
Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.
2.
ALS는 유전적으로 다양한 질병이다. 최소한 15개의 ALS 관련 유전자 부위가 밝혀졌고, 가족의 ALS의 약 30%에서 원인이 되는 유전자가 알려져 있다. 산발적인 유형에서는 근본적인 요인들이 잘 알려져있지 않다. 운동뉴런의 상처는 여러 병원성 경로의 복잡한 상호 작용을 통해 일어난다는 현재의 견해와 함